HGH 191AA

What is HGH 191AA?

HGH 191AA (Somatropin) is a recombinant human growth hormone consisting of 191 amino acids in a single polypeptide chain. It is identical in structure to endogenous pituitary-derived growth hormone, with a molecular weight of approximately 22,124 Da. HGH 191AA is produced via recombinant DNA technology and has been one of the most extensively studied peptide hormones in biomedical research.

Research Applications

• Growth Hormone Signaling: HGH 191AA binds to the growth hormone receptor (GHR), activating the JAK2-STAT5 signaling cascade. It is widely used in preclinical studies to investigate GH/IGF-1 axis modulation.
• Metabolic Research: Extensive research has examined HGH 191AA's effects on lipid metabolism, glucose homeostasis, and protein synthesis in various tissue models.
• Cell Proliferation Studies: HGH 191AA serves as a reference standard in studies of chondrocyte proliferation, osteoblast differentiation, and musculoskeletal tissue remodeling.
• Body Composition Research: Preclinical and clinical studies have utilized HGH 191AA to investigate changes in lean mass, adipose tissue distribution, and bone mineral density.
• Receptor Binding Assays: As a full-length, properly folded recombinant protein, HGH 191AA is the gold-standard ligand for GHR binding affinity studies.

Compound Information

• Structure: 191 amino acid single-chain polypeptide, two disulfide bonds
• Molecular Weight: 22,124 Da
• CAS Number: 12629-01-5
• Appearance: White lyophilized powder
• Dosage: 24 IU (8mg) per vial
• Solubility: Reconstitute with sterile water or bacteriostatic water

Specifications

• Purity: >99% (HPLC & SEC verified)
• Form: Lyophilized powder
• Bioactivity: Confirmed via Nb2 cell proliferation assay
• Container: Sealed vial (3mL flip-top)
• Storage: 2-8°C before reconstitution; -20°C for long-term
• Shelf Life: 2+ years when stored properly
• Certificate of Analysis available on request

Peer-Reviewed References

• Møller N, Jørgensen JO. "Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects." Endocr Rev. 2009.
• Bartke A, et al. "Growth hormone and aging: updated review." World J Mens Health. 2019.
• Reed ML, et al. "Structure-function relationships in human growth hormone." Biochem J. 1999.
• Savine R, Sönksen P. "Growth hormone — hormone replacement for the somatopause?" Horm Res. 2000.

For research use only. Not for human consumption. All products are sold strictly for laboratory and research purposes.