DSIP

What is DSIP?

Delta Sleep-Inducing Peptide (DSIP) is a nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. It was first isolated in 1977 from the cerebral venous blood of rabbits in an induced state of delta-wave sleep, and it has been the subject of sleep, stress and neuroendocrine research ever since.

Research Applications

• Sleep Architecture: DSIP is named for the delta-wave activity observed in the studies that first characterised it, and remains a reference compound in research on slow-wave sleep.
• Stress Response: Preclinical work has examined DSIP's influence on the hypothalamic-pituitary-adrenal axis and on markers of stress adaptation.
• Neuroendocrine Signalling: DSIP has been studied for its effects on the release of pituitary hormones, including somatostatin and corticotropin.
• Nociception: Research has explored DSIP's interaction with endogenous opioid pathways and pain-threshold models.

Compound Information

• Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
• Molecular Weight: 848.8 Da
• CAS Number: 62568-57-4
• Appearance: White lyophilized powder

Specifications

• Purity specification: >99%
• Form: Lyophilized powder
• Container: Sealed vial (3mL flip-top)
• Storage: -20°C or below, protected from light
• Shelf Life: 2+ years when stored properly
• Certificate of Analysis available on request

Peer-Reviewed References

• Schoenenberger GA, Monnier M. "Characterization of a delta-electroencephalogram (-sleep)-inducing peptide." Proc Natl Acad Sci USA. 1977.
• Graf MV, Kastin AJ. "Delta-sleep-inducing peptide (DSIP): a review." Neurosci Biobehav Rev. 1984.
• Iyer KS, McCann SM. "Delta sleep-inducing peptide (DSIP) inhibits the release of somatostatin from the rat hypothalamus in vitro." Neuroendocrinology. 1987.

For research use only. Not for human consumption. All products are sold strictly for laboratory and research purposes.