PT-141

What is PT-141?

PT-141, also known as Bremelanotide, is a synthetic cyclic heptapeptide melanocortin receptor agonist. It is a metabolite of the peptide Melanotan II, with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH. PT-141 acts on melanocortin receptors (primarily MC3R and MC4R) in the central nervous system rather than the vascular system, distinguishing its mechanism from other compounds studied in similar research contexts.

Research Applications

• Melanocortin Receptor Research: PT-141 is a non-selective melanocortin receptor agonist with high affinity for MC3R and MC4R subtypes. It has been used extensively in preclinical studies to map melanocortin signaling pathways in the CNS.
• Central Nervous System Signaling: Unlike vascular-acting compounds, PT-141 activates neural pathways originating in the hypothalamus, making it a valuable tool for studying CNS-mediated physiological responses.
• Behavioral Pharmacology: Preclinical studies in animal models have utilized PT-141 to investigate the role of melanocortin receptors in motivated behavior, appetite regulation, and energy homeostasis.
• Receptor Binding Studies: PT-141 serves as a reference agonist in melanocortin receptor binding assays and functional studies due to its well-characterized pharmacological profile.

Compound Information

• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
• Molecular Weight: 1,025.2 Da
• CAS Number: 189691-06-3
• Appearance: White lyophilized powder
• Solubility: Soluble in sterile water and bacteriostatic water

Specifications

• Purity: >99% (HPLC verified)
• Form: Lyophilized powder
• Container: Sealed vial (3mL flip-top)
• Storage: -20°C or below, protected from light and moisture
• Shelf Life: 2+ years when stored properly
• Certificate of Analysis available on request

Peer-Reviewed References

• Molinoff PB, et al. "PT-141: a melanocortin agonist for the treatment of sexual dysfunction." Ann N Y Acad Sci. 2003.
• Pfaus JG, et al. "A role for melanocortins in the CNS regulation of male and female sexual function." Ann N Y Acad Sci. 2003.
• Rosen RC, et al. "Bremelanotide (PT-141): overview of preclinical and clinical studies." J Sex Med. 2006.
• Hadley ME, Dorr RT. "Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization." Peptides. 2006.

For research use only. Not for human consumption. All products are sold strictly for laboratory and research purposes.