Semax

What is Semax?

Semax is a synthetic peptide derived from the adrenocorticotropic hormone (ACTH) fragment 4-10 with the addition of a Pro-Gly-Pro C-terminal tripeptide for enhanced stability. Its sequence is Met-Glu-His-Phe-Pro-Gly-Pro. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax has been extensively studied in both preclinical and clinical research settings.

Research Applications

• Neurotrophic Activity: Semax has been shown to upregulate the expression of brain-derived neurotrophic factor (BDNF) and its receptor TrkB in preclinical models, suggesting a role in neuronal survival and plasticity.
• Cognitive Research: Studies in animal models have demonstrated Semax's effects on learning, memory consolidation, and attention processes through modulation of monoaminergic and cholinergic neurotransmitter systems.
• Neuroprotective Properties: Preclinical research has explored Semax's ability to reduce oxidative damage and support neuronal viability under ischemic conditions.
• Immune Modulation: Research indicates Semax influences the expression of genes related to immune response and inflammation in brain tissue.

Compound Information

• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
• Molecular Weight: 813.9 Da
• CAS Number: 80714-61-0
• Appearance: White lyophilized powder

Specifications

• Purity: >99% (HPLC verified)
• Form: Lyophilized powder
• Container: Sealed vial (3mL flip-top)
• Storage: -20°C or below, protected from light
• Shelf Life: 2+ years when stored properly
• Certificate of Analysis available on request

Peer-Reviewed References

• Dolotov OV, et al. "Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus." Brain Res. 2006.
• Agapova TY, et al. "Effect of Semax on the temporary dynamics of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) gene expression." Mol Biol. 2008.
• Gusev EI, et al. "Neuroprotective effects of semax in acute cerebral ischemia." Zh Nevrol Psikhiatr Im S S Korsakova. 2005.

For research use only. Not for human consumption. All products are sold strictly for laboratory and research purposes.